The elusive tau molecular structures: can we translate the recent breakthroughs into new targets for intervention?

Abstract : Insights into tau molecular structures have advanced significantly in recent years. This field has been the subject of recent breakthroughs, including the first cryo-electron microscopy structures of tau filaments from Alzheimer's and Pick's disease inclusions, as well as the structure of the repeat regions of tau bound to microtubules. Tau structure covers various species as the tau protein itself takes many forms. We will here address a range of studies that help to define the many facets of tau protein structures and how they translate into pathogenic forms. New results shed light on previous data that need now to be revisited in order to update our knowledge of tau molecular structure. Finally, we explore how these data can contribute the important medical aspects of this research-diagnosis and therapeutics.
Complete list of metadatas

Cited literature [119 references]  Display  Hide  Download

https://hal-amu.archives-ouvertes.fr/hal-02055894
Contributor : François Devred <>
Submitted on : Monday, March 4, 2019 - 12:30:48 PM
Last modification on : Thursday, March 7, 2019 - 4:17:26 PM
Long-term archiving on : Wednesday, June 5, 2019 - 2:18:10 PM

File

28 Acta Neuropathologica Com 2...
Files produced by the author(s)

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Citation

Yann Fichou, Youssra Al-Hilaly, François Devred, Caroline Smet-Nocca, Philipp Tsvetkov, et al.. The elusive tau molecular structures: can we translate the recent breakthroughs into new targets for intervention?. Acta Neuropathologica Communications, BioMed Central part of Springer Science, 2019, 7 (1), ⟨10.1186/s40478-019-0682-x⟩. ⟨hal-02055894⟩

Share

Metrics

Record views

263

Files downloads

71